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Qrr RNA : ウィキペディア英語版
Qrr RNA

Qrr (Quorum regulatory RNA) is a non-coding RNA that is thought to be involved in the regulation of quorum sensing in ''Vibrio'' species. It is believed that these RNAs, guided by a protein, Hfq, can mediate the destabilisation of the quorum-sensing master regulators LuxR/HapR/VanT mRNAs.
Qrr operates as part of a negative feedback loop which regulates the shift in cell state from that of low density populations to that in high density populations. In ''Vibrio harveyi'', Qrr binds and represses expression of the ''luxR'' mRNA transcript, a master regulator of quorum-sensing genes. At higher population densities, increased autoinducer concentration leads to termination of ''qrr'' transcription hence derepression of ''luxR''.〔
There are 5 different ''qrr'' genes (Qrr1-5) in ''V. harveyi''; of these, qrr2, 3 and 4 are activated by LuxR.
==References==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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